厄贝沙坦片联合氢氯噻嗪片治疗92例轻中度高血压的临床分析

目的探讨氢氯噻嗪片联合厄贝沙坦片治疗轻中度高血压的临床疗效。方法选择2010年6月至2011年6月已确诊的轻中度原发性高血压患者184例,随机分为观察组和对照组各92例,对照组予以口服厄贝沙坦片150mg,1次/d,观察组在对照组治疗基础上加服氢氯噻嗪片12.5mg,1次/d,总疗程8周。于治疗前与治疗8周末进行心电图、血尿常规、血生化、电解质、尿酸等检查。每2周随访坐位血压、心率1次。结果观察组总有效率91.30%,对照组总有效率73.91%,两组差异有统计学意义(P<0.01);两组SBP和DBP均下降,且治疗组的收缩压和舒张压下降均较对照组更明显,两组差异显著具有统计学意义(P<0.001)。两组均无因严重不良反应。结论厄贝沙坦片和氢氯噻嗪片二者联合对轻中度高血压患者降压效果更显著,对代谢影响不明显,不良反应小,值得临床推广。

Irbesartan Tablets Combined Hydrochlorothiazide Tablets in the Treatment of Clinical Analysis of 92 Cases of Mild to Moderate Hypertension

Objective To investigate the the hydrochlorothiazide hydrochloride tablets irbesartan tablets in the treatment of mild to moderate hypertension clinical efficacy. Methods June 2010 to June 2011 have been confirmed in patients with mild to moderate essential hypertension of 184 cases were randomly divided into observation group and control group 92 cases, the control group was treated with oral irbesartan tablets 150mg, 1 hydrochlorothiazide plus service times/d, the observation group in the control group on the basis of thiophene hydrochloride tablets 12.5mg, 1 times/d for 8 weeks. Electrocardiogram, urinalysis, blood chemistry, electrolytes, uric acid examination before treatment and treatment at week 8. Follow-up every two weeks sitting blood pressure, heart rate 1. Results total efficiency of 91.30% in the control group the total effective ＇rate 73.91%, the difference was statistically significant （P〈0.01） ; two sets of SBP and DBP decreased, and systolic and diastolic blood pressure decreased compared with the treatment group control group, the difference was significant statistically significant （P〈 0.001 ） . There were no serious adverse reaction. Conclusion irbesartan tablets and hydrochlorothiazide tablets hydrochlorothiazide their combination antihypertensive effect in patients with more mild to moderate hypertension, had no obvious effect on the metabolic side effects, and is worthy of clinical