GDNF and bFGF are differentially involved in glial cell differentiation and neurite bundle formation in cultures from chick embryonic ciliary ganglia |
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Authors: | Zamburlin Pollyanna Gilardino Alessandra Ariano Paolo Lovisolo Davide Distasi Carla |
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Institution: | Dipartimento di Biologia Animale e dell'Uomo, I-10123 Turin, Italy. |
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Abstract: | We have shown that the neurotrophic factors glial cell line-derived neurotrophic factor (GDNF) and basic fibroblast growth factor (bFGF) exert different effects on glial cells in cultures from chick embryo ciliary ganglia. bFGF acts as a mitogen on glial cells, and induces their aggregation to neuronal bodies; after 48 h of culture no glial cells could be observed along neurites. GDNF has no proliferative role; in contrast, it promotes the expression of the differentiative marker O4 and the association of glial cell bodies to neurites to form robust bundles. |
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