| STAT1和STAT2在磷脂酰乙醇胺诱导肝癌HepG2细胞生长抑制中的作用 |
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| 引用本文： | 刘利英,黄辰,李宗芳,王爱英,胡晓岩,倪磊,于林,宋土生.STAT1和STAT2在磷脂酰乙醇胺诱导肝癌HepG2细胞生长抑制中的作用[J].南方医科大学学报,2011,31(2):256-258. |
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| 作者姓名： | 刘利英 黄辰 李宗芳 王爱英 胡晓岩 倪磊 于林 宋土生 |
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| 作者单位： | 刘利英,黄辰,王爱英,胡晓岩,倪磊,于林,宋土生,LIU Li-ying,HUANG Chen,WANG Ai-ying,HU Xiao-yan,NI Lei,YU Lin,SONG Tu-sheng(环境与疾病相关基因教育部重点实验室生物医学基础研究中心/医学院遗传学与分子生物学系,陕西,西安,710061);李宗芳,LI Zong-fang(医学院第二附属医院,陕西,西安,710004) |
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| 摘 要： | 目的探讨磷脂酰乙醇胺(PE)诱导肝癌HepG2细胞生长抑制中STAT1和STAT2的作用。方法实验以人肝癌细胞系HepG2为材料,分别设置了空白对照组、0.125、0.25、0.5和1 mmol/L PE处理组。应用MTT法检测细胞生长,荧光免疫组化检测细胞内STAT1和STAT2表达。结果与对照组相比,PE各处理组对HepG2细胞生长的抑制作用具有剂量依赖性,并可诱导STAT1和STAT2高表达,而AG490可以部分逆转PE的效应。结论 STAT1和STAT2参与了PE诱导HepG2细胞的生长抑制过程。
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| 关 键 词： | 磷脂酰乙醇胺 STAT1 STAT2 肝癌 HepG2细胞 |
STAT1 and STAT2 participate in growth inhibition of human hepatoma HepG2 cells induced by phosphatidylethanolamine |
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| LIU Li-ying,HUANG Chen,LI Zong-fang,WANG Ai-ying,HU Xiao-yan,NI Lei,YU Lin,SONG Tu-sheng.STAT1 and STAT2 participate in growth inhibition of human hepatoma HepG2 cells induced by phosphatidylethanolamine[J].Journal of Southern Medical University,2011,31(2):256-258. |
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| Authors: | LIU Li-ying HUANG Chen LI Zong-fang WANG Ai-ying HU Xiao-yan NI Lei YU Lin SONG Tu-sheng |
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| Institution: | LIU Li-ying1,HUANG Chen1,LI Zong-fang2,WANG Ai-ying1,HU Xiao-yan1,NI Lei1,YU Lin1,SONG Tu-sheng1 1Key Laboratory of Environment and Genes Related to Diseases of Ministry of Education,Xi'an Jiaotong University College of Medicine,Xi'an 710061,China,2Second Affiliated Hospital,Xi'an 710004 |
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| Abstract: | Objective To investigate the roles of STAT1 and STAT2 in growth inhibition induced by phosphatidylethanolamine(PE) in human hepatoma HepG2 cells.Methods The growth of HepG2 cells exposed to 0.125,0.25,0.5 and 1.0 mmol/L PE was assessed by MTT assay,and the expressions of STAT1 and STAT2 were analyzed using immunocytochemical assay.Results PE inhibited the growth of HepG2 cells in a dose-dependent manner and increased the expression of STAT1 and STAT2 in comparison with those in the control group.AG490,an in... |
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| Keywords: | STAT1 STAT2 |
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