| 脂肪组织局部肾素-血管紧张素系统的调节及其在糖尿病中的作用 |
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| 引用本文： | 方萍,汤正义.脂肪组织局部肾素-血管紧张素系统的调节及其在糖尿病中的作用[J].国际内分泌代谢杂志,2011,31(3):187-189. |
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| 作者姓名： | 方萍 汤正义 |
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| 作者单位： | 上海市内分泌代谢病研究所,上海交通大学医学院附属瑞金医院内分泌代谢病科,上海市内分泌代谢病临床中心,200025 |
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| 摘 要： | 脂肪组织局部存在肾素-血管紧张素系统(RAS)中几乎所有的组分,这些组分不仅构成局部RAS,而且是循环中RAS各成分的重要来源.多种因素包括肥胖、胰岛素等均可以影响脂肪组织中RAS各成分的表达.脂肪组织局部RAS活性增加,可作用于脂肪细胞,抑制脂肪细胞分化及脂质代谢,并影响脂肪细胞因子分泌,同时血管紧张素可作用于周围组...
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| 关 键 词： | 肾素-血管紧张素系统 脂肪组织 糖尿病 胰岛素抵抗 |
The regulation of local adipose tissue RAS and its effects on diabetes |
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| FANG Ping,TANG Zheng-yi.The regulation of local adipose tissue RAS and its effects on diabetes[J].International JOurnal of Endocrinology and Metabolism,2011,31(3):187-189. |
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| Authors: | FANG Ping TANG Zheng-yi |
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| Abstract: | All the components of renin-angiotensin system(RAS)were found in adipose tissue,and this components not only compose the local RAS but also secreted as important source to circular RAS.Multipie factors,such as obesity and insulin,could adjust RAS expression in adipose tissue.The activation of local adipose tissue RAS could suppress the differentiation of adipocytes,lipometabelism and affect adipokine secretion.Moreover,angiotensin could act upon the surrounding tissues,therefore induce insulin resistance and participate in the pathological process of type 2 diabetes mellitns by exacerbating inflammatory reaction,and oxidative stress. |
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| Keywords: | Renin-angiotensin system Adipose tissue Diabetes mellitus Insulin resistance |
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