恶性黑色素瘤生物免疫治疗的研究进展

恶性黑色素瘤是一种恶性程度极高的皮肤肿瘤,病人发生转移后应用传统治疗方法很难达到有效治疗.自从恶性黑色素瘤的肿瘤抗原表位被发现后,恶性黑色素瘤的免疫治疗就开始成为研究热点.过继性细胞治疗临床应用研究在近几年内得到快速发展,其中疗效最好的当属肿瘤浸润淋巴细胞(TIL)回输治疗,其治疗有效率可以达到70%以上.同时,各种用...

Progress Study on the biological and immune therapy for malignant melanoma

Melanoma is the most serious type of skin cancer and hard to be cured by traditional therapy when metastasis occurs in the patients. Since the immunogenicity of the melanoma was discovered,the biological and immune therapy for this tumour became a hot spot of research. The clinical research on adoptive cell transfer has developed rapidly in recent years and the most remarkable effecs obtained were the infusing of autotumor infiltrating lymphocyte with over a 70% partial response. In the mean time,the research on monoclonal antibodies and signalling pathway inhibitor has been progressing quickly. These researchs have provided new approaches to the biological and immune therapy. The effects of various medicine with different mechanisms will be demonstrated in the near future,especially ipilimumab,the anti-CTLA-4 monoclonal antibody and PLX4032,an highly selective inhibitor of BRAF.