| 祛风通络方对阿霉素肾病大鼠Pododcin mRNA表达及足细胞足突形态的影响 |
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| 引用本文： | 孙万森,赵艳龙,任艳芸,马巧亚.祛风通络方对阿霉素肾病大鼠Pododcin mRNA表达及足细胞足突形态的影响[J].南方医科大学学报,2011,31(2):244-247. |
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| 作者姓名： | 孙万森 赵艳龙 任艳芸 马巧亚 |
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| 作者单位： | 孙万森,马巧亚,SUN Wan-sen,MA Qiao-ya(西安交通大学医学院第二附属医院中医科,陕西,西安,710004);赵艳龙,ZHAO Yan-long(第四军医大学唐都医院肾内科,陕西,西安,710038);任艳芸,REN Yan-yun(陕西中医学院附属医院肾内科,陕西,咸阳,712000) |
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| 摘 要： | 目的观察祛风通络方对阿霉素肾病大鼠Pododcin mRNA表达及足细胞足突形态的影响,探讨祛风通络方治疗肾病蛋白尿的分子生物学机制。方法 SD大鼠随机分为空白组和造模组,以阿霉素(6 mg/kg)尾静脉注射法造模,模型成功后将大鼠随机分为模型组、祛风组、激素组和苯那组,并给予相应干预。用RT-PCR法测定肾组织Podocin mRNA表达,透射电镜观察足细胞及足突形态变化。结果 (1)模型成功与空白组比较,造模组大鼠Podocin mRNA表达明显下调(P<0.01),足细胞足突融合甚至消失,足细胞有脱落、细胞数明显减少。(2)干预结束后与模型组比较,各干预组PodocinmRNA表达均上调(P<0.01);祛风组足细胞及足突形态改善明显。结论祛风通络方可能通过上调阿霉素肾病大鼠肾小球足细胞Podocin mRNA表达,改善足细胞及足突形态结构而达到防治蛋白尿的目的。
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| 关 键 词： | 祛风通络方 蛋白尿 Podocin 足细胞 |
Effects of Qufengtongluo Recipe on podocin mRNA expression and podocyte morphology in rats with adriamycin-induced nephropathy |
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| SUN Wan-sen,ZHAO Yan-long,REN Yan-yun,MA Qiao-ya.Effects of Qufengtongluo Recipe on podocin mRNA expression and podocyte morphology in rats with adriamycin-induced nephropathy[J].Journal of Southern Medical University,2011,31(2):244-247. |
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| Authors: | SUN Wan-sen ZHAO Yan-long REN Yan-yun MA Qiao-ya |
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| Institution: | SUN Wan-sen1,ZHAO Yan-long2,REN Yan-yun3,MA Qiao-ya1 1Department of Traditional Chinese Medicine,Second Affiliated Hospital,Xi'an Jiaotong University College of Medicine,Xi'an 710004,China,2Department of Nephrology,Tangdu Hospital,Fourth Military University,Xi'an 710038,3Department of Nephrology,Affiliated Hospital,Shaanxi University of Traditional Chinese Medicine,Xianyang 712000 |
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| Abstract: | Objective To observe the effects of Qufengtongluo Recipe(QFTLR) on the expression of podocin mRNA and podocyte morphology in rats with adriamycin-induced nephropathy(AN),and explore the possible mechanism mediating the therapeutic effect of QFTLR on nephropathic proteinuria.Methods SD rats were randomized into normal control group,AN model group(established by a single injection of adriamycin via the tail vein),and 3 intervention groups with QFTLR,prednisone,or benazepril treatment.After the corresponding t... |
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| Keywords: | Podocin |
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