| 脑源性神经营养因子及信号传导通路与缺氧缺血性脑损伤 |
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| 引用本文： | 金宝. 脑源性神经营养因子及信号传导通路与缺氧缺血性脑损伤[J]. 国际儿科学杂志, 2011, 38(3): 267-270. DOI: 10.3760/cma.j.issn.1673-4408.2011.03.020 |
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| 作者姓名： | 金宝 |
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| 作者单位： | 上海交通大学附属儿童医院重症医学科,200040 |
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| 基金项目： | 上海市科委基础研究重点项目 |
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| 摘 要： | 脑源性神经营养因子(BDNF)是神经营养因子家族中最重要的一员,在神经系统分布广泛.BDNF通过激活酪氨酸受体激酶B(TrkB)及其信号传导通路对神经元的存活、生长、功能、形态和可塑性等起着重要的作用.PI3K/Akt和MAPK/ERK细胞内信号传导通路是BDNF发挥神经保护作用的两条主要途径.近年研究发现,BDNF及...
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| 关 键 词： | 脑源性神经营养因子 酪氨酸受体激酶B 信号传导通路 缺氧缺血性脑损伤 儿童 |
Recent approach of brain-derived neurotrophic factor and signal transduction pathways in hypoxic ischemic brain damage |
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| JIN Bao. Recent approach of brain-derived neurotrophic factor and signal transduction pathways in hypoxic ischemic brain damage[J]. International Journal of Pediatrics, 2011, 38(3): 267-270. DOI: 10.3760/cma.j.issn.1673-4408.2011.03.020 |
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| Authors: | JIN Bao |
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| Abstract: | Brain-derived neurotrophic factor(BDNF)belongs to the neurotrophin family and abundantly expressed in the nervous system.It plays an essential role in the survival,development,function,morphogenesis and plasticity of neurons by binding to the tyresine receptor kinase B(TrkB)and subsequent downstream activation of several signal transduction pathways in the nervous system. The PI3K/Akt and the MAPK/ERK DathWays ale two major intracellular signaling network activated by BDNF involved in survival of neurons.Becently.it is investigated that BDNF and TrkB are involved in the pathophysiology of hypoxic ischemic brain damage (HIBD)and in the mechanism of action of therapeutic agents.Therefore we image changing the internal or external condIitions can increase the expression of BDNF,thsu reduce the nervous system damage of HIBD. |
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| Keywords: | Brain-derived neurotrophie factor Tyrosine receptor kinase B Signal transduction pathways Hypoxic ischemic brain damage Child |
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