维生素D与过敏性疾病相关性的研究进展

过敏性疾病的患病率在全世界呈上升趋势.流行病学调查结果显示西方发达国家维生素D制剂的使用与过敏性疾病发病率同步增加,早期补充维生素D可能增加患过敏性疾病的风险.近期研究发现维生素D缺乏的地区过敏性疾病发病率也较高,多数学者认为维生素D缺乏与过敏性疾病流行相关.研究发现维生素D参与过敏性疾病的免疫反应,如抑制Th1细胞、树突细胞发育及Th2细胞分化,参与维持肠黏膜上皮细胞屏障完整性,但无证据表明维生素D过量或缺乏可导致过敏性疾病的发生.

Abstract：

The prevalence of allergy diseases is increasing globally. Epidemiological surveies showed that the increased allergy prevalence rates followed the time trend of rickets prophylaxis in western countries. and vitamin D supplement increased the risk of allergy in early stage.Currently,most of investigators think that vltamin D deficiency may be one of the risk factors for allergy diseases.Laboratory investigations showed that vitamin D inhibited Th1、dendritic cell(DC)and Th2 cell proliferating,and keeped on epithelial suIfaces barrier tunction.However,no study has found generating of allergy disease is associated with vitamin D deftciency or excess.

Progress of the relationship between vitamin D and allergy diseases

The prevalence of allergy diseases is increasing globally. Epidemiological surveies showed that the increased allergy prevalence rates followed the time trend of rickets prophylaxis in western countries. and vitamin D supplement increased the risk of allergy in early stage.Currently,most of investigators think that vltamin D deficiency may be one of the risk factors for allergy diseases.Laboratory investigations showed that vitamin D inhibited Th1、dendritic cell(DC)and Th2 cell proliferating,and keeped on epithelial suIfaces barrier tunction.However,no study has found generating of allergy disease is associated with vitamin D deftciency or excess.