特异性免疫治疗机制的研究进展

特异性免疫治疗是治疗过敏性疾病的最有效方法,至今已有90多年的历史.其机制尚未明确,早期的研究重点集中于循环抗体和效应细胞,目前主要集中于免疫治疗对T细胞的作用及由此引起的一系列细胞因子的变化、CD4+调节性T细胞亚群、修饰抗原递呈细胞诱导免疫耐受、免疫效应细胞募集机制、单克隆技术支持下的重组变应原、变应原DNA疫苗、...

Progress in mechanism of specific immunotherapy

Specific immunotherapy(SIT)is the most effective therapy for allergies.Although specific immunotherapy has existed for more than 90 years and has made a great progress,its mechanism is not well defined.Early studies focused on the circulating antibodies and effector cells.At present.the research of the mechanism mainly concentrates on the immune therapy on T cells role and a series of cytokines arising from the change,CD4+ regulatory T cells subsets,modified APC induction of immune tolerance,aggregation mechanism of immune effector cells,restructuring allergens under the support of monoclonal antibody technique,allergens DNA vaccines,allergens coupling adjuvants.This essay is a review of progress in mechanism of specific immunotherapy.