神经梅毒的研究进展

神经梅毒的发生可能与梅毒螺旋体的神经侵袭性和宿主细胞免疫力有关,HIV感染会增加神经梅毒的发生率.脑脊液RPR检测可以作为性病研究实验室试验的替代方法用于神经梅毒的诊断,脑脊液中tau蛋白和趋化因子CXCL13检测对于神经梅毒的诊断也具有一定的提示意义.对于青霉素过敏者,可试用多西环素或头孢曲松作为替代药物.在驱梅治疗的基础上,辅助治疗可以起到改善症状和增加疗效的作用.血清RPR滴度的动态观测可试用于神经梅毒的疗效判断.

Abstract：

The development of neurosyphilis may be associated with Treponema pallidum neuroinvasion and host immunity. Human immunodeficiency virus (HIV) infection may increase the incidence of neurosyphilis. Cerebrospinal fluid (CSF)-rapid plasma reagent (RPR) test can be applied as a substitute for venereal disease research laboratory test (VDRL) to the diagnosis of neurosyphilis. Detection of tau protein and chemokine CXCL13 in CSF also has great value in the diagnosis of neurosyphilis. For patients allergic to penicillin, doxycycline or ceftriaxone may serve as alternative drugs. Adjuvant therapy may benefit the improvement of syphilis symptoms and strengthen the efficacy of antisyphilitic treatment. Dynamic observation of serum RPR titer can be used to monitor the treatment efficacy in patients with neurosyphilis.

Progress in neurosyphilis

The development of neurosyphilis may be associated with Treponema pallidum neuroinvasion and host immunity. Human immunodeficiency virus (HIV) infection may increase the incidence of neurosyphilis. Cerebrospinal fluid (CSF)-rapid plasma reagent (RPR) test can be applied as a substitute for venereal disease research laboratory test (VDRL) to the diagnosis of neurosyphilis. Detection of tau protein and chemokine CXCL13 in CSF also has great value in the diagnosis of neurosyphilis. For patients allergic to penicillin, doxycycline or ceftriaxone may serve as alternative drugs. Adjuvant therapy may benefit the improvement of syphilis symptoms and strengthen the efficacy of antisyphilitic treatment. Dynamic observation of serum RPR titer can be used to monitor the treatment efficacy in patients with neurosyphilis.