| 噻唑烷二酮类药物不良反应的再认识 |
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| 引用本文： | 刘晓云,刘超. 噻唑烷二酮类药物不良反应的再认识[J]. 国际内分泌代谢杂志, 2008, 28(6) |
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| 作者姓名： | 刘晓云 刘超 |
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| 作者单位： | 南京医科大学第一附属医院内分泌科,210029;南京医科大学第一附属医院内分泌科,210029 |
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| 基金项目： | 江苏省卫生厅医学领军人才项目 |
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| 摘 要： | 噻唑烷二酬类药物(TZDs)通过激活过氧化物酶体增殖物活化受体-γ,增加外周组织对胰岛素的敏感性而改善胰岛素抵抗,以其独特的作用机制在口服抗糖尿病药物中独树一帜.然而,近年来有关TZDs不良反应的报道日渐增多.在肝毒性、体重增加、水肿、心力衰竭等不良反应得到确认的同时,关于其心血管与骨代谢方面的不良反应更是备受关注.科学面合理地分析与认识这些不良反应,对指导临床实践具有重要意义.
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| 关 键 词： | 噻唑烷二酬 肝毒性 体重 心力衰竭 心血管事件 骨折 |
Reevaluation on the adverse effects of thiazolidinediones |
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| LIU Xiao-yun,LIU Chao. Reevaluation on the adverse effects of thiazolidinediones[J]. International JOurnal of Endocrinology and Metabolism, 2008, 28(6) |
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| Authors: | LIU Xiao-yun LIU Chao |
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| Abstract: | By activating peroxisomc-proliferator-activated receptor γ, thiazolidinediones (TZDs)can improve insulin sensitivity and decrease insulin resistance in the peripheral tissue which serve as a characteristic mechanism among oral antidiabetic medications.However, there are many case reports concerning the adverse effects of TZDs, such as hepatotoxicity, weight gain, edema and heart failure.The potential cardiotoxieity and increased bone fraeture in female subjects have aroused a great debate.Therefore, it is important to reevaluate the side effects of TZDs in clinical practice. |
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| Keywords: | Thiazolidinediones Hepatotoxicity Weight Heart failure Cardiovascular events Bone fracture |
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