老年2型糖尿病患者血清脂联素和早期动脉粥样硬化的关系

目的分析老年2型糖尿病患者血清脂联素水平和早期动脉粥样硬化的关系。方法将55例老年2型糖尿病患者根据颈动脉内膜中层厚度(carotid intima-media thickness,CIMT)进行分组,29例CIMT≤0.9mm的2型糖尿病患者为非动脉粥样硬化组,另外26例CIMT>0.9mm或发现动脉斑块的2型糖尿病患者为动脉粥样硬化组,并配对选取25例非糖尿病的健康者为对照组。同时收集入选者的临床资料,包括年龄、性别、体质量指数(BMI)、踝臂指数(ABI)、糖化血红蛋白(HbA1c)、血糖、空腹血脂以及胰岛素等生化指标,并计算稳态模型(HomaModel)的胰岛素抵抗指数HomaIR=(FINS×FPG)/22.5,取其自然对数值;用酶联免疫法测定入选者的血清脂联素。结果(1)动脉粥样硬化组的血清脂联素显著低于非动脉粥样硬化组及对照组。(2)相关性研究显示脂联素与血糖、HbA1c、高敏C反应蛋白(hs-CRP)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、甘油三酯(TG)、CIMT负相关(r=-0.30,r=-0.32,r=-0.23,r=-0.66,r=-0.83,r=-0.63,r=-0.7...

Correlation between serum adiponectin and early atherosclerosis in aged patients with type 2 diabetes mellitus

Objective To study the correlation between serum adiponectin and early atherosclerosis in aged patients with type 2 diabetes mellitus (DM). Methods Fifty-five aged patients with type 2 DM, enrolled in this study, were divided into non-atherosclerosis group with their carotid intima-media thickness (CIMT)≤0.9 mm (n=29) and atherosclerosis group with their CIMT >0.9 mm (n=26). Twenty-five healthy individuals served as a control group. Clinical data including age, sex,BMI, ABI, HbA_(1c),fasting glucose and insulin were collected.Insulin resistance index in Homa model was calculated following the equation: Homa IR=FINS×FPG)/22.5. Serum adiponectin level was measured by ELISA. Results The serum adiponectin level was significantly lower in atherosclerosis group than in non-atherosclerosis and control groups (P<0.01). The adiponectin level was negatively correlated with the levels of glucose, HbA_(1c), hs-CRP, TC, LDL-C, TG and CIMT but positively correlated with HDL-C and ABI (P<0.05). Multiple stepwise regression analysis showed that LDL-C and HDL-C were the independent factors influencing the serum adiponectin level. Conclusion Low serum adiponectin level is correlated with atherosclerosis in aged type 2 DM patients.