| 离子型X线造影剂碘羟拉酸的合成 |
| |
| 引用本文： | 邹霈, 刘娅灵, 谢敏浩, 何拥军, 吴军, 王洪勇, 罗世能. 离子型X线造影剂碘羟拉酸的合成[J]. 中国现代应用药学, 2007, (6): 475-476. |
| |
| 作者姓名： | 邹霈 刘娅灵 谢敏浩 何拥军 吴军 王洪勇 罗世能 |
| |
| 作者单位： | 江苏省原子医学研究所,江苏,无锡,214063 |
| |
| 摘 要： | 目的离子型X线造影剂碘羟拉酸的合成。方法以5-硝基异酞酸为原料,经酯化、酰胺化、还原、碘化和乙酰化反应等步骤制得碘羟拉酸。结果合成产物经元素分析、核磁共振谱和质谱确证了化学结构。结论该工艺路线方法简便,原料易得,适合工业化生产。
|
| 关 键 词： | 非离子型X线造影剂 碘羟拉酸 化学合成 |
| 文章编号： | 1007-7693（2007）06-0475-92 |
| 收稿时间： | 2006-09-25 |
| 修稿时间： | 2006-09-25 |
Synthesis of Ioxitalamic Acid as Ionic X-ray Contrast Agent |
| |
| ZOU Pei, LIU Ya-ling, XIE Min-hao, HE Yong-jun, Wu Jun, Wang Hong-yong, LUO Shi-neng. Synthesis of Ioxitalamic Acid as Ionic X-ray Contrast Agent[J]. Chinese Journal of Modern Applied Pharmacy, 2007, (6): 475-476. |
| |
| Authors: | ZOU Pei LIU Ya-ling XIE Min-hao HE Yong-jun Wu Jun Wang Hong-yong LUO Shi-neng |
| |
| Abstract: | OBJECTIVE To synthesize Ioxitalamic acid,a ionic x-ray contrast agent.METHODS Ioxitalamic acid was synthesized by steps of esterification,amidation,reduction,iodization and acetylation from 5-nitro-isophthalic acid.RESULTS The chemical structure of the synthesized product were confirmed by element analysis,1H-NMR,13C-NMR,MS(FAB).CONCLUSION The process can be easily controlled and is suitable for a scale production. |
| |
| Keywords: | non-ionic x-ray contrast agent Ioxitalamic acid chemical synthesis |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
| 点击此处可从《中国现代应用药学》浏览原始摘要信息 |
|
点击此处可从《中国现代应用药学》下载全文 |
|
