| 一氧化氮和一氧化氮合酶基因多态性与糖尿病视网膜病变 |
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| 引用本文： | 董娟,郎平,吴昌凡.一氧化氮和一氧化氮合酶基因多态性与糖尿病视网膜病变[J].国际眼科杂志,2010,10(11):2144-2146. |
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| 作者姓名： | 董娟 郎平 吴昌凡 |
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| 作者单位： | 皖南医学院弋矶山医院眼科,中国安徽省芜湖市,241000 |
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| 摘 要： | 糖尿病视网膜病变(diabetic retinopathy,DR)是重要致盲性眼病之一,其发生和进展与血糖水平、疾病病程、环境及遗传等多种因素有关。一氧化氮(NO)作为一种重要的血管活性物质,与DR中毛细血管闭塞、微循环障碍、内皮细胞增殖相关。一氧化氮合成酶(NOS)是NO合成过程中的关键酶,我们就NO和NOS基因多态性与DR的关系进行综述。
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| 关 键 词： | 糖尿病视网膜病变 一氧化氮 一氧化氮合成酶 基因多态性 |
NO and NOS on genetic polymorphisms of diabetic retinopathy |
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| Juan Dong,Ping Lang and Chang-Fan Wu.NO and NOS on genetic polymorphisms of diabetic retinopathy[J].International Journal of Ophthalmology,2010,10(11):2144-2146. |
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| Authors: | Juan Dong Ping Lang and Chang-Fan Wu |
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| Institution: | Department of Ophthalmology,Yijishan Hospital of Wannan Medical College,Wuhu 241000,Anhui Province,China;Department of Ophthalmology,Yijishan Hospital of Wannan Medical College,Wuhu 241000,Anhui Province,China;Department of Ophthalmology,Yijishan Hospital of Wannan Medical College,Wuhu 241000,Anhui Province,China |
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| Abstract: | ·Diabetic retinopathy(DR)is one of important eye diseases that may cause blindness.Its occurrence and development is related to blood glucose level,duration of diabetes,environment and genetics.Nitric oxide(NO)is an important vasoactive substance which correlate with capillary occlusion,microcirculation disturbance,endothelial cell proliferation in DR.Nitric oxide synthase(NOS)is now accepted as a key enzyme of NO synthesis.The functions of NO and NOS on genetic polymorphism to DR are summarized in this review.· |
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| Keywords: | diabetic retinopathy nitric oxide nitric oxide synthase genetic polymorphism |
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