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| 心房颤动患者碱性成纤维细胞生长因子及受体mRNA表达 | |
| 引用本文： | 林亚洲,宋伟,陈林,杨志平,张建成,昊卫,柯丹,许春萱.心房颤动患者碱性成纤维细胞生长因子及受体mRNA表达[J].福建医药杂志,2009,31(6):8-11. |
| 作者姓名： | 林亚洲 宋伟 陈林 杨志平 张建成 昊卫 柯丹 许春萱 |
| 作者单位： | 1. 福建省立医院心血管病研究所心内科 350001 2. 福建省龙岩市第一医院心内科 3. 武警福建总队医院心内科 |
| 基金项目： | 福建省科技厅青年科技人才创新项目 |
| 摘 要： | 目的检测碱性成纤维细胞生长因子（bFGF）及其受体FGFR-1和HSPG在心房颤动（房颤）患者心房组织中的mRNA表达，探讨房颤患者心房纤维化的分子机制。方法75例风湿性心脏瓣膜病（风心病）接受换瓣手术者分为3组，其中窦性心律组34例，阵发性房颤组n例，持续性房颤组30例，于术中获取右心耳组织，采用半定量RT-PCR技术测定bFGF、FGFR1和HSPG mRNA含量。结果与窦性心律组比较，bFGF、FG—FR-1和HSPG的mRNA在阵发性（P〈0．05）和持续性房颤组（P〈0．05）的表达均明显上调。同时，bFGF的mRNA水平与房颤持续时间（r=0．330．P=0．005）及左心房内径呈正相关（r=0．342，P=0．003）。结论心房组织中bFGF、FGFR-1和HSPG的mRNA表达上调可能是导致房颤患者心房纤维化的分子机制之一，与房颤的发生和维持有关。 |
| 关 键 词： | 心房颤动 碱性成纤维细胞生长因子 心房纤维化 |
mRNA expression of basic fibroblast growth factor and receptors in human atria during atrial fibrillation |
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| Lin Yazhou,Song Wei,Chen Lin,Yang Zhiping,Zhang Jiancheng,Wu Wei,Ke Dan,Xu Chunxuan.mRNA expression of basic fibroblast growth factor and receptors in human atria during atrial fibrillation[J].Fujian Medical Journal,2009,31(6):8-11. | |
| Authors: | Lin Yazhou Song Wei Chen Lin Yang Zhiping Zhang Jiancheng Wu Wei Ke Dan Xu Chunxuan |
| Institution: | Lin Yazhou,Song Wei,Chen Lin,Yang Zhiping,Zhang Jiancheng,Wu Wei,Ke Dan,Xu Chunxuan.Department of Cardiology,Research Institute of Cardiovascular Diseases,Fujian Provincial Hospital,Fuzhou 350001,China |
| Abstract: | Objective To investigate the significance and alteration of mRNA expression of basic fibroblast growth factor(bFGF) and its receptors includes FGFR-1 and HSPG related to atrial fibrosis in patients with atrial fibrillation(AF).Methods Seventy-five patients with rheumatic heart disease who underwent heart valve replacement surgery were divided into three groups.Thirty-four patients were in sinus rhythm group,11 patients were in paroxysmal AF group and 30 patients were in persistent AF group.Semi-quantitative... |
| Keywords: | Atrial fibrillation Basic fibroblast growth factor Atrial fibrosis |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |