| 肝间质成分层粘连蛋白和透明质酸的研究及临床应用 |
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| 引用本文： | 高锋,谭金兴.肝间质成分层粘连蛋白和透明质酸的研究及临床应用[J].第二军医大学学报,1993,14(5):457-461. |
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| 作者姓名： | 高锋 谭金兴 |
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| 作者单位： | 长征医院临床免疫中心 200003
(高锋，孔宪涛，谢映华，王笑利，范列英)，第二军医大学病理生理学教研室 200433(谭金兴) |
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| 摘 要： | 作者对肝脏内的细胞外间质成分层粘连蛋白和透明质酸进行了细胞学研究和病人血清含量检测，发现ＬＮ和ＨＡ可明显抑制人胎肝细胞的增殖和脯氨酸合成的参入，而在慢性肝病尤其是肝硬变病人血清中的含量明显高于正常人，并且和肝功能损害程度呈正相关。ＬＮ和ＨＡ联合诊断肝硬变的符合率为９０％。提示ＬＮ、ＨＡ在肝纤维化发生机制中可能起抑制作用，而在血清学方面可以作为判断慢性肝病损伤程度和诊断纤维化的指标。
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| 关 键 词： | 间质成分 层粘连蛋白 透明质酸 肝 |
Extracellular Matrix in Liver: Experimental Study and Clinical Application |
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| Gao Feng,Kong Xiantao,Xie Yinghua,Wang Xiaoli,Fan Lieying,Tan jinxing.Extracellular Matrix in Liver: Experimental Study and Clinical Application[J].Academic Journal of Second Military Medical University,1993,14(5):457-461. |
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| Authors: | Gao Feng Kong Xiantao Xie Yinghua Wang Xiaoli Fan Lieying Tan jinxing |
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| Abstract: | Laminin(LN) and hyaluronie acid (HA) are extracellular matrix in liver. The effects of LN and HA on human fetal liver cells proliferation and collagen synthesis were observed and serum levels of LN and HA were assayed m patients with liver diseases by an enzyme immunoassay method. Both LN and HA had a significant effect on the inhibition of cell proliferation and collagen production. However, serum levels of LN and HA were significantly increased in liver cirrhosis comparing with healthy controls and with patients with non-liver diseases. The results suggest that LN and HA may play a role in the feed-back inhibition mechanism in liver fibrogencsis, and assay of LN and HA in serum may be useful to the diagnosis of liver fibrosis. |
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| Keywords: | exlracellular matrix laminin hyaluronic acid liver cells liver fibrosis |
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