基于CiteSpace的HPV疫苗相关文献科学知识图谱可视化分析

目的：梳理人乳头瘤病毒（HPV）疫苗研究的历史进程、现状，预测未来发展趋势。方法：通过梳理HPV疫苗相关文献，以中国知网学术期刊数据库（CNKI）、万方数据知识服务平台为数据来源，检索到文献1 584篇，从1995年1月-2018年9月，统计每年的文献数，把搜索到的文献以Refworks的格式导出，用CiteSpace软件对作者、研究机构、关键词、学科、主题进行可视化分析，得到聚类视图或时间线视图。结果：2006年前后文献数涨幅较大，2010-2014年文献数有些许回落，2014年之后有较大幅度上升。该领域的研究者和机构分布广，团队较多，但研究较为广泛或深入的机构较少，不同机构间的合作少。大学生、HPV疫苗、与HPV疫苗相关的影响因素、与HPV疫苗指南相关研究和该疫苗对女性的应用为研究前沿。结论：对HPV疫苗的研究历经28年，仍然是如今的热门话题，在今后的研究中，应加强机构合作，使优秀人才互通有无，将研究立体化，增加各机构的综合程度，扩大影响力。研究者在进行这一领域研究时，学习核心作者的研究成果是有必要的。

Visualization Analysis of HPV Vaccine-related Literatures with Knowledge Map Based on CiteSpace

Objective：To understand the history and current development of HPV vaccine, and to predict the trend of HPV vaccine. Methods：Using CNKI and WangFang databases, 1 584 articles from January 1995 to Septemper 2018 were retrieved. HPV vaccine-related literatures were exported in the format of refworks. The cluster view or timeline view was described on the author, institution, key words, term and category, which was based on the cluster analysis using CiteSpace software. Results：The number of literatures was significantly increased around 2006, fell slightly from 2010 to 2014, and increased again after 2014. Although research teams and institutions in this field were widely distributed, the extensive or detailed studies were from few institutions, and the cooperative study was much less. The research hot words were college student, human papillomavirus vaccine, influencing factors related to HPV vaccine, study related to HPV vaccine guideline and application of HPV vaccine in women. Conclusions：Study on HPV vaccine is still a hot topic although it went through 28 years. In the future, the diversified cooperation in different institutions or teams should be encouraged. It is necessary for those new researchers to understand the findings of core authors and the developing trend in this field.