急性心肌梗死与不稳定型心绞痛患者血栓前体蛋白和肌酸激酶的检测

为了解检测血栓前体蛋白对急性冠状动脉综合征转归的早期诊断价值 ,5 1例临床确诊冠心病患者分为不稳定型心绞痛和急性心肌梗死两组 ,采用酶联免疫吸附法检测各组血浆中血栓前体蛋白含量 ,采用干化学法同步检测患者血清磷酸肌酸激酶及其同工酶。结果发现 ,急性心肌梗死组 2 5例患者血栓前体蛋白均值为 9.9± 3.9mg L ,不稳定型心绞痛组 2 6例患者血栓前体蛋白均值为 2 .6± 1.7mg L ,前者明显升高 ,差别有显著性意义 (P <0 .0 1) ;急性心肌梗死组磷酸肌酸激酶均值为 5 95± 4 32u L ,磷酸肌酸激酶同工酶均值为 10 1± 74u L ,不稳定型心绞痛亚组磷酸肌酸激酶均值为 137± 4 0u L ,磷酸肌酸激酶同工酶均值为 10± 7u L ,前者亦明显升高 ,差别均有显著意义(分别为P <0 .0 5和P <0 .0 1)。结果提示 ,血栓前体蛋白对急性冠状动脉综合征具有早期诊断和鉴别价值

Measurement of Thrombus Precursor Protein and Creatine Kinase in Patients with Acute Myocardial Infarction and Unstable Pectoris Angina

Aim To detect the early diagnosis value of thrombus precursor protein (TpP) in acute coronary artery syndrome. Methods 51 cases of coronary artery disease were divided into two subgroups of unstable pectoris angina and acute myocardial infarction. Thrombus precursor protein and creatine kinase (CK and CKMB )concentration were determined in all patients. Resluts Thrombus precursor protein concentration of the acute myocardial infarction subgroup increased significantly than the unstable pectoris angina subgroup(9.9±3.9 mg/L vs 2.6±1.8 mg/L,p<0.01);also,CK and CKMB concentration of the acute myocardial infarction subgroup increased significantly than the unstable pectoris angina subgroup (595±432 u/L vs 137±40 u/L,p<0.05; 101±74 u/L vs 10±7 u/L,p<0.01,respectively). Conclusion Thrombus precursor protein concentration of the acute myocardial infarction subgroup increases significantly,but not in the unstable pectoris angina subgroup. Thrombus precursor protein has differentiated and early diagnostic value for the acute myocardial infarction in patients with acute coronary artery syndrome.