阿糖胞苷致急性白血病患者心包积液、急性心包填塞死亡

1例36岁男性患者因急性白血病给予DA方案（柔红霉素100mg,1次/d静脉滴注,第1～3天;阿糖胞苷早100mg、晚150mg静脉滴注,第1～7天）化疗。入院第6天胸部CT检查示心包增厚;入院第11天患者出现咳嗽、气短、心悸。BP145/105mmHg,HR120次/min,心音遥远。结合超声心动图,考虑为心包积液、急性心包填塞。急行心包穿刺术,穿刺失败,患者于入院第12天因呼吸循环衰竭死亡。

Death from pericardial effusion and acute cardiac tamponade caused by cytarabine in a patient with acute leukaemia

A 36-year-old man with acute leukemia received a DA regimen（an IV infusion of daunomycin 100 mg once daily on days 1-3＋an IV infusion of arabinoside 100 mg in the morning and 150 mg at night on days 1-7）.On day 6 of admission,a chest CT scan showed pericardial thickening.On day 11,the patient developed cough,shortness of breath,palpitation.His blood pressure was 145/105 mm Hg and heart rate was 120 beats/min.His heart sound was distant.Based on the findings of ultrasound cardiogram,pericardial effusion and acute cardiac tamponade were considered.He underwent pericardiocentesis immediately;however,the treatment failed.On day 12,the patient died from respiratory and circulatory failure.