Auto-associative amphiphilic polysaccharides as drug delivery systems |
| |
Authors: | Hassani Leila N Hendra Frédéric Bouchemal Kawthar |
| |
Affiliation: | UMR CNRS Physico-chemistry, Pharmacotechny and Biopharmacy, Université Paris-Sud, School of Pharmacy, Chatenay Malabry, France. |
| |
Abstract: | Self-assembly of amphiphilic polysaccharides provides a positive outlook for drug delivery systems without the need for solvents or surfactants. Various polymeric amphiphilic polysaccharides undergo intramolecular or intermolecular associations in water. This type of association, promoted by hydrophobic segments, led to the formation of various drug delivery systems such as micelles, nanoparticles, liposomes and hydrogels. Here, we review a selection of the most important amphiphilic polysaccharides used as drug delivery systems and their pharmaceutical applications. Attention focuses on amphiphilic chitosan owing to its unique properties such as excellent biocompatibility, non-toxicity and antimicrobial and bioadhesive properties. |
| |
Keywords: | |
本文献已被 ScienceDirect PubMed 等数据库收录! |
|