Antiangiogenic agents as second-line therapy for advanced non-small cell lung cancer |
| |
Authors: | Reckamp Karen L |
| |
Affiliation: | Department of Medical Oncology and Therapeutics Research, City of Hope and Beckman Research Institute, 1500 E. Duarte Rd., MOB 1001, Duarte, CA 91010, USA. kreckamp@coh.org |
| |
Abstract: | With the approval of the antiangiogenic antibody bevacizumab in non-small cell lung cancer (NSCLC) and other malignancies, the tumor vasculature has emerged as a worthwhile therapeutic target. Second-line therapies have the potential to improve overall survival and quality of life over best supportive care alone. Accordingly, phase II and phase III studies are actively evaluating antiangiogenic treatments in the second-line setting in NSCLC, and results are awaited. Such therapies include antiangiogenic antibodies, small molecule inhibitors, and vascular-disrupting agents. This review will present the current landscape of angiogenesis inhibition in NSCLC, focusing on use as second-line therapy. |
| |
Keywords: | Angiogenesis Non-small cell lung cancer Tyrosine kinase inhibitor Vascular disrupting agent Second-line therapy |
本文献已被 ScienceDirect PubMed 等数据库收录! |
|