内镜止血联用大剂量洛赛克治疗溃疡病大出血

目的：探讨内镜止血联用大剂量洛赛克治疗消化性溃疡大出血的临床价值。方法：对３２例溃疡病大出血患者进行内镜治疗，然后将内镜止血成功的２１例继续抑酸治疗，１０例用大剂量洛赛克，１１例用常规剂量西米替丁。结果：内镜即刻止血成功２１例，失败１例。

Endoscope Hemostasis Combine with High Does Losec Treatment for Peptic Ulcer Hemorrhea

Purpose: To explore the clinical value of endoscope hemostasis combine with high does of losec traeatment for peptic ulcer hemorrhea. Methods: 22 cases of peptic ulcer hemorrhea were treated by endoscope. 21 cases of them were succeed in treatment and then given further treatment with acid inhibitor. Among the 21 cases. 10 cases treatment with high does losec and 11 cases with routine does cimetidine. Results: 21 cases succeed in endoscope hemostasis immediatly and 1 case fail. 5 cases were rebleeding after endoscope hemostasis, which is treatment combine with cimetidine, none of which treatment combine with high does losec is rebleeding, and those 5 cases rebleeding were stop in 48 hours after treatment with high does losec. The rebleeding rate of two groups (losec and cimetidine) is significant difference (x 2 test P<0.05). Conclusions: Endoscope hemostasis can rapidly shorten the procedure of peptic ulcer hemorrhea. High does losec can rapidly improve intra gastric pH, maintaining pH in a high level, protecting gastric and duodenal mucosa, reinforcing the efficacy of endoscope hemdstasis and protecting it form current rebleeding. It may be a big promotion of the cure rate of peptic ulcer hemorrhea by endoscope hemostasis combine with high does losec treatment. It is a practial and useful methods in clinical therapy.