Polymorphism of prion protein gene in sheep of Inner Mongolian,China |
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| Authors: | Cai-Xia Han Hong-Xiang Liu Yi-Xin Lu Ming-Xin Song De-Ming Zhao Xiang-Mei Zhou Li-Feng Yang Xiao-Yun Li |
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| Affiliation: | (1) College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, People’s Republic of China;(2) Department of Histopathology, Addenbrooke’s Hospital, University of Cambridge, Hills Road, Cambridge, CB2 2QQ, UK;(3) State Key Lab of Agrobiotechnology, National Animal Transmissible Spongiform Encephalopathy Laboratory, College of Veterinary Medicine, China Agricultural University, Beijing, 100094, People’s Republic of China; |
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| Abstract: | Susceptibility to natural scrapie in sheep is associated with polymorphisms at codons 136, 154 and 171 of the prion protein (PrP) gene. To assess the risk of scrapie in sheep raised in China, DNA from 30 sheep of two breeds was isolated, amplified and sequenced for the PrP gene. The ovine PrP gene was found to be highly homogenous. The genotype associated with high susceptibility to scrapie (VRQ) was absent, whereas that associated with the resistance (ARR) was present in 6.7% of sheep examined. ARK was also rare (6.7%). ARQ that is associated with an intermediate susceptibility was the genotype observed in the most of sheep examined (86.6%). These data suggest that Chinese sheep of Mongolian sheep breed are susceptible to scrapie. |
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