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Antimycobacterial anthraquinone-chromanone compound and diketopiperazine alkaloid from the fungus Chaetomium globosum KMITL-N0802
Authors:Kanokmedhakul Somdej  Kanokmedhakul Kwanjai  Phonkerd Nutchanat  Soytong Kasem  Kongsaeree Palangpon  Suksamrarn Apichart
Affiliation:Department of Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen, Thailand. somdej@kku.ac.th
Abstract:Investigation of the fungus Chaetomium globosum KMITL-N0802 led to the isolation of a novel anthraquinone-chromanone compound named chaetomanone along with seven known compounds, ergosterol, ergosteryl palmitate, chrysophanol, chaetoglobosin C, alternariol monomethyl ether, echinuline and isochaetoglobosin D. These compounds were characterized by spectroscopic methods. Chaetomanone and echinulin exhibited activity towards Mycobacterium tuberculosis.
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