槐甙胶囊防治绝经后骨质疏松症的疗效观察

目的:观察槐甙胶囊防治妇女绝经后骨质疏松疗效。方法:22例腰椎(L1,L2,L3,L4)骨密度低于一个标准差以下的绝经后患者入选,每日口服槐甙胶囊60mg,连续3个月。治疗前后检查腰椎和前臂骨密度;血清雌二醇、睾酮、尿促卵泡素(folliclestimulatinghormone,FSH)、骨钙素、血浆I型胶原羧基前体肽(procollagentypeIC-terminalpeptide,PICP)、尿脱氧吡啶酚(deoxypyridinoline,Dpyr);观察治疗前后腰背静息痛和运动痛。结果:槐甙胶囊治疗前后绝经后患者腰椎骨密度差异有显著性意义:犤(0.769±0.206),(0.816±0.212)g/cm2,t=-2.855,P=0.009;L3:(0.915±0.188),(0.958±0.205)g/cm2,t=-2.137,P=0.044;L2-4:(0.889±0.197),(0.92±0.204)g/cm2,t=-2.256,P=0.035犦;睾酮犤(0.283±0.131),(0.236±0.133)ng/mL犦和FSH犤(52.988±23.113)mIU/mL,(44.225±18.144)mIU/ml犦均有显著下降(t=2.9864,P=0.007;t=2.624,P=0.016);骨吸收指标尿Dpyr显著下降(t=3.856,P=0.001);治疗后患者的腰背静息痛和运动通有显著性意义(静息痛:t=9.566,P=0.001;运动痛:t=6.797,P=0.001)。结论:槐甙胶囊有改善绝经后患者腰椎骨密度和抑制骨吸收的作用,能明显减轻患者的腰背疼痛。

Observation on therapeutic effect of sophoricoside capsule for postmenopausal osteoporosis

AIM:To observe the therapeutic effect of Sophoricoside Capsules on postmenopausal osteoporosis. METHODS:Twenty two-postmenopausal osteoporosis patients with low density of L1- 4 were administered Sophoricoside Capsules,60 mg per day for 3 months.Before and after treatment,the density of lumbar vertebrae and forearm,the serous estradiol,testosterone,follicle stimulating hormone(FSH),Osteocalcin,procollagen type I C-terminal peptide(PICP),and deoxypyridinoline(Dpyr) were tested to observe the rest pain and motion pain of the lower back. RESULTS:There was a big difference in the density of lumbar vertebrae of postmenopausal osteoporosis patients treated with the Sophoricoside Capsule.L1:(0.769± 0.206)g/cm2 ,(0.816± 0.212) g/cm2,t=- 2.855, P=0.009; L3:(0.915± 0.188) g/cm2,(0.958± 0.205) g/cm2,t=- 2.137, P =0.044; L2- 4: (0.889± 0.197) g/cm2,(0.92± 0.204) g/cm2, t=- 2.256, P=0.035]; testosterone(0.283± 0.131) ng/ml,( 0.236± 0.133) ng/mL] and FSH(52.988± 23.113) mIU/mL, (44.225± 18.144) mIU/mL] decreased remarkably(t=2.9864, P=0.007; t=2.624, P=0.016); Dpyr reduced obviously( t=3.856, P=0.001); and the rest pain and motion pain of lower back were relieved markedly after the treatment(rest pain:t=9.566, P=0.001; motion pain:t=6.797, P=0.001). CONCLUSION: The Sophoricoside Capsule improves the density of lumbar vertebrae, inhibits the bone absorption, and noticeably alleviated the lumbar pain greatly.