| 具有抗肿瘤活性的槲皮素衍生物研究进展 |
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| 引用本文： | 杨扬,郭举. 具有抗肿瘤活性的槲皮素衍生物研究进展[J]. 中草药, 2018, 49(6): 1468-1475 |
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| 作者姓名： | 杨扬 郭举 |
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| 作者单位： | 武汉工程大学绿色化工过程教育部重点实验室, 湖北 武汉 430205,武汉工程大学绿色化工过程教育部重点实验室, 湖北 武汉 430205 |
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| 基金项目： | 湖北省教育厅科学研究计划指导性项目（B2016057）；新型反应器与绿色化学工艺湖北省重点实验室开放基金（201704） |
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| 摘 要： | 槲皮素是黄酮类天然产物,具有多种药理活性,近年来其优良的抗肿瘤活性受到了国内外学者的关注,但由于特殊的分子结构导致其水溶性较差,影响了其临床应用价值,因此对其结构进行化学修饰以改善生物利用度或提高抗肿瘤活性成为了研究的热点。对近年来具有抗肿瘤活性的槲皮素酯类衍生物、金属配合物、醚类衍生物及其他衍生物的研究进展进行综述,以期为槲皮素抗肿瘤新药的开发提供科学依据。
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| 关 键 词： | 槲皮素 黄酮类 结构修饰 抗肿瘤活性 衍生物 |
| 收稿时间： | 2017-12-19 |
Research progress on active quercetin derivatives with antitumor effect |
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| YANG Yang and GUO Ju. Research progress on active quercetin derivatives with antitumor effect[J]. Chinese Traditional and Herbal Drugs, 2018, 49(6): 1468-1475 |
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| Authors: | YANG Yang and GUO Ju |
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| Affiliation: | Key Laboratory for Green Chemical Process of Ministry of Education, Wuhan Institute of Technology, Wuhan 430205, China and Key Laboratory for Green Chemical Process of Ministry of Education, Wuhan Institute of Technology, Wuhan 430205, China |
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| Abstract: | Quercetin, as a natural product of flavonoids, has many pharmacological activities, and its excellent antitumor activity has been concerned by many scholars at home and abroad in recent years. However, quercetin is poorly water-soluble because of its special molecular structure, which affects its medicinal value in clinic. Therefore, the chemical modification of its structure to improve its bioavailability or antitumor activity has become a hot research topic. In this paper, recent advances in the study of quercetin derivatives with anticancer activity, such as quercetin ester derivatives, metal complexes, ether derivatives, and other derivatives are reviewed, which provides scientific basis for the future development of antitumor drugs from quercetin. |
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| Keywords: | quercetin flavonoids structural modification antitumor activity derivatives |
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