静脉注射维生素C对透析后肾性贫血的治疗效果

目的 探讨静脉注射维生素C对透析后肾性贫血的治疗效果。 方法 将80例接受透析治疗的肾性贫血患者依据数字表法随机分为研究组和对照组,每组40例。两组患者均给予皮下注射重组人红细胞生成素(EPO)和蔗糖铁静脉滴注,研究组在此基础上加用维生素C静脉推注治疗。对比两组患者血红蛋白(Hb)、血红细胞指标、铁代谢相关指标及不良反应。 结果 研究组患者治疗后各时段Hb、红细胞比容(Hct)、红细胞数量(RBC)和未溶解红细胞比例(RBC%)均显著高于对照组和治疗前,且差异有统计学意义(P <0.05)。同时研究组患者治疗后各时段的血清铁(SI)、血清铁蛋白(SF)、转铁蛋白饱和度(TSAT)均显著高于治疗前和对照组,且差异有统计学意义(P <0.05)。两组患者不良反应的差异无统计学意义(P >0.05)。 结论 透析时静脉推注维生素C可以有效改善肾性贫血患者的贫血症状和铁代谢。

Clinical efficacy of Vitamin C injection in the treatment of renal anemia after dialysis

Objective To study the clinical efficacy of vitamin C injection in the treatment of renal anemia after dialysis. Methods A total of 80 patients with renal anemia were randomly divided into study group and control group according to random number tables, with 40 patients in each group. All the patients were treated with EPO subcutaneous injection, iron sucrose intravenous drip and dialysis. Additionally, patients in the study group were treated with vitamin C injection. The hemoglobin level, red blood cell indexes, iron metabolism indexes and adverse reaction between the two groups were compared. Results After treatment, the hemoglobin level, RBC count and hematocrit in the study group were significantly higher than those in the control group and before treatment (P <0.05), the blood SI, SF, TSAT in the study group were also significantly higher than those in the control group and before treatment (P <0.05). There was no significant difference of adverse reaction between the two groups (P >0.05). Conclusion The therapy of vitamin C injection during dialysis has better clinical efficacy on renal anemia, which can relieve anemia symptom and improve iron metabolism.