茶碱微乳经皮吸收及药代动力学研究

目的:研究茶碱微乳在家兔不同皮肤部位给药后的经皮吸收及药代动力学。方法:采用HPLC测定血浆中茶碱的浓度,应用基于Guass-Newton-Zhu原理设计的NLFTZ计算机程序对实验数据进行解析。结果:茶碱微乳经背部肺腧穴给药后的血药浓度高于非穴位给药,有极显著性差异(P

Transdermal absorption and pharmacokinetics of theophylline microemulsion

Aim:To investigate the transdermal absorption and pharmacokinetics of theophylline microemulsions on the acupuncture points of rabbits.Methods: Theophylline concentration in plasma was determined by HPLC.The pharmacokinetic parameters were estimated by application of NLFTZ program based on the principle of Guass-Newton-Zhu.Results: The plasma concentrations of theophylline following administration via Feishu point were statistically significantly higher than those via conventional application(P<0.01).The plasma level-time profile of theophyllinesTDS was better fitted to a complex model consisting of two independent zero-order absorption processes with no lag-times and first-order elimination process.Conclusion: The transdermal delivery of theophylline microemulsion showed characteristics,i.e.double-path ways and double processes."Special transport route" might exist in the double-path ways of penetration through acupuncture point while slow transport occurs through non-point.