| 细菌伴侣蛋白Skp诱导白细胞趋化作用的研究 |
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| 引用本文： | 施磊,孔珺. 细菌伴侣蛋白Skp诱导白细胞趋化作用的研究[J]. 中国医科大学学报, 2005, 34(3): 225-226 |
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| 作者姓名： | 施磊 孔珺 |
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| 作者单位： | 1. 中国医科大学附属第一医院耳鼻喉科,辽宁,沈阳,110001
2. 中国医科大学附属第一医院,眼科,辽宁,沈阳,110001 |
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| 摘 要： | 目的:证明大肠杆菌伴侣蛋白Skp诱导单核细胞和分叶核白细胞产生趋化运动.方法:分离提纯Skp,通过分子量测定和氨基端的氨基酸测序予以证实.体外趋化实验分析其对白细胞的趋化作用.结果:Skp对单核细胞和分叶核白细胞具有趋化活性.结论:Skp是一种细菌源性的趋化因子.
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| 关 键 词： | 白细胞趋化 伴侣蛋白Skp |
| 文章编号： | 0258-4646(2005)03-0225-02 |
| 修稿时间： | 2004-12-27 |
Leukocyte chemotaxis induced by bacterial chaperone protein Skp |
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| SHI Lei,KONG Jun. Leukocyte chemotaxis induced by bacterial chaperone protein Skp[J]. Journal of China Medical University, 2005, 34(3): 225-226 |
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| Authors: | SHI Lei KONG Jun |
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| Abstract: | Objective: To verify whether bacterial chaperone protein Skp can induce the chemotactic responses on monocytes and polymorphonuclear leukocytes (PMNs) or not. Methods: We purified bacterial leukocyte chemotactic factor, and Skp was confirmed by using NH 2-terminal amino acid sequence analysis and mass spectrometric analysis. The leukocyte chemotactic capacities of Skp were identified in vitro. Results: Skp attracted PMNs and monocytes as in the cases of the other chemotactic factors. Conclusion: The Skp induced the chemotactic response of monocytes and PMNs. |
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| Keywords: | leukocyte chemotaxis chaperone protein Skp |
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