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Association between vitamin D receptor gene polymorphisms, falls, balance and muscle power: results from two independent studies (APOSS and OPUS) |
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| Authors: | R Barr H Macdonald A Stewart F McGuigan A Rogers R Eastell D Felsenberg C Glüer C Roux D M Reid |
| Institution: | 1. Bone and Musculoskeletal Research Programme, University of Aberdeen, Aberdeen, UK 6. Clinical and Molecular Osteoporosis Research Unit, Department of Clinical Sciences Malm?, Lund University, Malm?, Sweden 2. Academic Unit of Bone Metabolism, School of Medicine and Biomedical Sciences, University of Sheffield, Sheffield, UK 3. Centre Muscle & Bone Research, Charité-Campus Benjamin Franklin, Free University and Humboldt University, Berlin, Germany 4. Medizinische Physik, Klinik für Diagnostische Radiologie, Universit?tsklinikum Schleswig-Holstein, Campus Kiel, Kiel, Germany 5. Centre d’Evaluation des Maladies Osseuses, Service de Rhumatologie, H?pital Cochin, Université René Descartes, Paris, France 7. Division of Applied Medicine, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, UK |
| Abstract: | SummaryFall prevention is a key strategy for reducing osteoporotic fractures. We investigated the association between vitamin D receptor (VDR) polymorphisms and reported falls in postmenopausal women. Bsm1 polymorphisms were associated with falls, balance and muscle power measurements. These results may explain some of the excess fracture risk associated with VDR in some studies. |
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