金钱草提取物对高尿酸血症小鼠的影响

目的:研究金钱草水提取物对高尿酸血症小鼠影响。方法:选择化学诱导剂氧嗪酸钾盐作为尿酸酶抑制剂,ip小鼠造成高尿酸血症模型。采用磷钼酸还原法测定小鼠血清尿酸水平。不同剂量金钱草水提取物ig给药,持续3d。结果:金钱草水提取物(5.2,10.8,20.8g·kg^-1·d^-1)能显著地减少高尿酸血症小鼠血清尿酸水平,而对正常小鼠的血清尿酸水平无显著性影响。结论:金钱草水提取物对高尿酸血症小鼠具有降低血清尿酸水平作用。

Effects Of Aqueous Extract in Herba of Lysimachia christinae on Hyperuricemia in Mice

Objective: To study hypouricemic effect of aqueous extract of Lysimachia christinae on hyperuricemia in mice. Method: The uricase inhibitor potassium oxonate was used to induce hyperuricemia in mice,and serum uric acid level was determined with the phosphotungstic acid method. Result: The aqueous extract of Lysimachia christinae, when administered orally to the ox-onate-induced hyperuricemic mice at the doses of 5. 2, 10. 4 and 20. 8 g·kg^-1, was able to elicit dose-dependent hypouricemic effects. At these doses of the extract, the serum urate levels of the oxonate-pretreated mice showed no difference from the normal mice. In normal mice, however, oral administration of the extract at the same doses did not produce any observable hypouricemic effects. Conclusion: The aqueous extract of Lysimachia christinae possesses potent hypouricemic effects on models of hyperuricemia in mice pretreated with oxonate.