RETRACTED ARTICLE: Prevention of PONV with granisetron, droperidol or metoclopramide in patients with postoperative emesis |
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| Authors: | Yoshitaka Fujii Yuhji Saitoh Hiroyoshi Tanaka Hidcnori Toyooka |
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| Affiliation: | (1) Department of Anaesthesiology, University of Tsukuba Institute of Clinical Medicine, 2-1-1, Amakubo, 305 Tsukuba City, Ibaraki, Japan;(2) Department of Anaesthesiology and Critical Care Medicine, Tokyo Medical and Dental University School of Medicine, Bunkyo-ku, Tokyo, Japan;(3) Department of Anaesthesiology, Toridc Kyodo General Hospital, Toridc City, Ibaraki, Japan |
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| Abstract: | Purpose A high incidence of postoperative nausea and vomiting (PONV) has been noted in patients with a history of postoperative emesis. This study was undertaken to compare the efficacy of granisetron, droperidol and metoclopramide, in the prevention of PONV in such patients undergoing general anaesthesia for major gynaecological surgery. Methods In a randomised, double-blind study, 90 female patients received 2.5 mg granisetron, 1.25 mg droperidol or 10 mg metoclopramide (n = 30 of each)iv immediately before induction of anaesthesia. The same standard general anaesthetic technique, which consisted of isoflurane in nitrous oxide and oxygen, was used. Nausea, vomiting and safety assessments were performed continuously during the first 24 hr after anaesthesia. Results The incidence of PONV was 20% with granisetron, 57% with droperidol and 60% with metoclopramide (P < 0.05; overall Fisher’s exact probability test). No clinically adverse events were observed in any group. Conclusion Granisetron is more effective than droperidol or metoclopramide in preventing PONV in female patients with a history of postoperative emesis. |
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