急性脑梗死患者血清YKL-40与脑梗死分型的相关性研究

【目的】探讨血清炎性蛋白YKL-40与脑梗死临床分型和病因分型的关系，以指导临床诊治。【方法】应用ELISA方法检测91例急性脑梗死患者（发病48 h内）和34例健康对照者血清YKL-40的表达量，并对脑梗死患者进行CT分型、牛津郡社区卒中项目(OCSP)分型和治疗急性卒中实验(TOAST)分型，然后分析YKL-40表达量与各分型间的关系。【结果】急性脑梗死患者血清YKL-40表达量较健康对照组明显升高（P<0.001）；脑梗死患者CT分型、OCSP分型及TOAST分型各亚型YKL-40表达量不同（P<0.001），其中大面积梗死组、TACI组及CE组血清YKL-40含量明显高于其它亚组。【结论 】急性脑梗死患者血清YKL-40表达量明显升高，并且与病灶大小及病因有相关性，YKL-40可能对评估急性脑梗死患者的病情程度和临床预后具有提示作用，并对脑梗死的病因治疗具有指导作用。

Association between Serum YKL-40 in Patients with Acute Cerebral Infarction and Cerebral Infarction Classification

【Objective】 To determine and compare the level of serum YKL-40 at acute stage of cerebral infarction and to investigate the relationship among the levels of serum YKL-40 and different classification of acute ischemic stroke.【Methods】 Serum YKL-40 levels were measured by enzyme immunoassay in 91 patients with cerebral infarction(within 48 h on admission) and 34 healthy controls.The relationship among the YKL-40 and clinical classification and the etiologic subtype of stroke were investigated.【Results】The levels of serum YKL-40 were significantly increased in patients with cerebral infarction than the normal control subjects(P < 0.001).The levels of serum YKL-40 in large infarct group and TACI group and CE group were significantly higher than those in other groups according to different classification criteria.【Conclusions】 Serum YKL-40 level elevated after ischemic stroke and was related to infarct size and the etiology.The serum YKL-40 might be a new biological marker to predict the severity and prognosis of ischemic stroke.