Tau mRNA在胃癌组织中的表达及其临床意义

 目的 探讨Tau mRNA在胃癌组织中的表达及其临床意义。方法采用反转录-聚合酶链反应（RT-PCR）方法检测正常胃组织与胃癌组织中Tau mRNA的表达。结果Tau mRNA在胃癌组织中的表达高于在正常胃组织中的表达（P<0.05），并且高中分化胃癌组织Tau mRNA的表达低于低分化胃癌组织，无淋巴结转移胃癌组织Tau mRNA的表达低于有淋巴结转移胃癌组织且差异有统计学意义(P均<0.05)，TNM分期Ⅲ+Ⅳ期Tau mRNA的相对含量明显高于I+Ⅱ期（P<0.05），Tau mRNA含量在不同年龄、性别、病变长度中无明显差异（P均＞0.05）。结论胃癌组织中Tau mRNA表达水平的升高与胃癌的分化程度及转移有密切的关系。

Expression Its Clinical Significance of Tau mRNA in Gastric Carcinoma Tissues

Objective To elucidate the features of Tau mRNA expression in normal gastric tissue and gastric carcinoma tissue.Methods The expression of Tau mRNA was detected by RT-PCR in normal and carcinomatous gastric tissue.Results The expressing quantity of Tau mRNA was significantly higher in gastric carcinoma tissue than that in normal gastric tissue(P<0.05).The expression of Tau mRNA in well differentiated and moderately differentiated was lower than that in poorly differentiated gastric carcinoma.The expression of Tau mRNA in gastric carcinoma without lymph node metastasis was lower than that in gastric carcinoma with lymph node metastasis(P<0.05).The expression of Tau mRNA of TNM stage Ⅲ and Ⅳ was significantly higher than that of TNM stage I and Ⅱ(P<0.05).Correlations were not found between Tau mRNA and some other characteristics of gastric carcinoma such as age,gender,length of tumor(P>0.05).Conclusion The higher levels of Tau mRNA of gastric carcinoma was closely related to tumor differentiation degree and metastasis.