| 去卵巢小鼠海马内脑源性神经营养因子的表达 |
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| 引用本文： | 卢大华,杨德森,刘丹,李昌琪,罗学港. 去卵巢小鼠海马内脑源性神经营养因子的表达[J]. 中南大学学报(医学版), 2005, 30(1): 53-56 |
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| 作者姓名： | 卢大华 杨德森 刘丹 李昌琪 罗学港 |
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| 作者单位： | 中南大学1.湘雅医学院解剖学与神经生物学系，长沙 410013； 2.湘雅二医院精神卫生研究所，长沙 410011 |
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| 基金项目： | 湖南省自然科学基金(02JJY3022) |
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| 摘 要： | 目的：探讨小鼠卵巢切除后的不同时期脑源性神经营养因子（BDNF）在海马表达的变化。方法：用免疫组织化学染色结合图像分析检测BDNF在小鼠卵巢切除后海马CA各区与齿状回的表达。结果：在小鼠卵巢切除后4d BDNF的表达明显下降，14d BDNF的表达开始恢复，28d BDNF在海马的表达基本恢复到正常水平。结论：雌激素水平的下降在早期可减弱BDNF在小鼠海马的表达。
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| 关 键 词： | 脑源性神经营养因子 雌激素 海马 去卵巢小鼠 |
| 文章编号： | 1672-7347(2005)01-0053-04 |
| 收稿时间： | 2004-10-26 |
| 修稿时间： | 2004-10-26 |
Expression of brain-derived neurotrophic factor in hippocampus of ovariectomized mouse |
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| LU Da-hua,YANG De-sen,LIU Dan,LI Chang-qi,LUO Xue-gang. Expression of brain-derived neurotrophic factor in hippocampus of ovariectomized mouse[J]. Journal of Central South University. Medical sciences, 2005, 30(1): 53-56 |
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| Authors: | LU Da-hua YANG De-sen LIU Dan LI Chang-qi LUO Xue-gang |
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| Affiliation: | 1. Department of Anatomy and Neurobiology, Xiangya School of Medicine, Central South University, Changsha 410013,China;
2.Department of Mental Health, Second Xiangya Hospital, Changsha 410011,China |
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| Abstract: | Objective To explore the expression of brain-derived neurotrophic factor (BDNF) in the hippocampus after ovariectomy in mice. Methods BDNF levels were detected by immunohistochemistry combined image analysis in hippocampal CA regions and dentate gyrus of ovariectomized mice. Results The expression of BDNF in hippocampus of mice decreased significantly after the ovariectomy after 4 days. The recovery BDNF expression started 14 days after the ovariectomy and after 28 days, the expression of BDNF in hippocampus recovered to the normal level. Conclusion The decrease of estrogen in ovariectomized mice can weaken the expression of BDNF in hippocampus during the early stage. |
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| Keywords: | BDNF estrogen hippocampus ovariectomized mouse |
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