| 替比夫定治疗慢性乙型肝炎的Meta分析 |
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| 引用本文： | 沈国斌,王立坤,郑壬平. 替比夫定治疗慢性乙型肝炎的Meta分析[J]. 九江医学, 2011, 0(2) |
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| 作者姓名： | 沈国斌 王立坤 郑壬平 |
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| 作者单位： | 都昌县人民医院内科;临沂市人民医院感染科;九江市第一人民医院泌尿外科; |
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| 摘 要： | 目的:评价替比夫定治疗慢性乙型肝炎患者的疗效及安全性。方法:检索替比夫定和拉米夫定治疗慢性乙型肝炎随机对照研究文献,对治疗效果、安全性等进行Meta分析。结果:替比夫定在生化反应、病毒学应答、降低HBeAg滴度、病毒学突破以及耐药发生率等方面优于拉米夫定,但在HBeAg和HBsAg转阴率上二者差异无统计学意义。随着疗程延长,替比夫定在HBeAg转阴率上高于拉米夫定,但不良反应和肌酸激酶升高的机会也随之增加。结论:替比夫定比拉米夫定具有更强的抑制乙肝病毒复制的作用,须重视不良反应。
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| 关 键 词： | 慢性乙型肝炎 替比夫定 拉米夫定 |
Meta Analysis of LdT in the Treatment of Chronic Hepatitis B |
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| SHEN Guobin WANG Likun ZHENG Renping. Meta Analysis of LdT in the Treatment of Chronic Hepatitis B[J]. Jiujiang Medical Journal, 2011, 0(2) |
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| Authors: | SHEN Guobin WANG Likun ZHENG Renping |
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| Affiliation: | SHEN Guobin1 WANG Likun2 ZHENG Renping3 (1.Internal Medicine Department of Duchang County Hospital,jiujiang Jinagxi 332600 2.Infectious Desease Department of Linyi People's Hospital,Linyi,Shandong 276000 3.Urology Surgery Department of Jiujiang No.1 People's Hospital,Jiujiang,Jiangxi 332000) |
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| Abstract: | To evaluate the efficacy and safety of Telbivudine(LdT) and Lamivudine(LAM) in the treatment of chronic hepatitis B by meta-analysis,we have studied the relevant documents and materials.At the end of one-year treatment,LdT was better than LAM at the biochemical response,virological response,HBeAg loss,therapeutic response,while less than at the viral breakthrough and viral resistance,but there was no significant difference in the HBeAg seroconversion and HBsAg response.LdT was better than LAM at the HBeAg s... |
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| Keywords: | chronic hepatitis B Telbivudine Lamivudine |
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