Distribution of CCR5-Δ32 and CCR2–64I alleles in an Argentine Amerindian population |
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Authors: | A Mangano G Theiler L Sala M Capucchio L Fainboim L Sen |
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Institution: | Laboratorio de Biología Celular y Retrovirus, Hospital de Pediatría JP Garrahan, Buenos Aires, Argentina. |
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Abstract: | In order to evaluate the frequency distributions of CCR5-Delta 32 and CCR2-64I polymorphisms in an Amerindian population, we tested a total of 42 Chiriguanos individuals that are aboriginal inhabitants of the north west of Argentina. Only one carried the CCR5-Delta 32 allele (0.0238), while 17 out of 35 carried the CCR2-64I mutation, including one homozygous for the mutated allele (0.2571). Although the cohort studied is considered highly endogamic, the HLA genotyping revealed that 8 out of 42 subjects had a gene flow from Caucasian populations. The only heterozygous CCR5+/Delta 32 found and three heterozygous CCR2+/64I belonged to the admix group. In conclusion, the protective deletion CCR5-Delta 32 is practically absent in Chiriguanos whereas the CCR2-64I allele is highly frequent. |
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Keywords: | Amerindian CCR5 CCR2 polymorphisms |
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