Antiinflammatory activity of the iridoids kutkin,picroside-1 and kutkoside from Picrorhiza kurrooa |
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| Authors: | G B Singh Sarang Bani Surjeet Singh A Khajuria M L Sharma B D Gupta S K Banerjee |
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| Institution: | 1. Pharmacology Department, Regional Research Laboratory, Canal Road, Jammu-Tawi 180001, India;2. Natural Products Chemistry Division, Regional Research Laboratory, Canal Road, Jammu-Tawi 180001, India |
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| Abstract: | Powdered roots of Picrorhiza kurrooa (PK), its alcoholic extract (AEPK) and active constituents kutkin, picroside-1 and kutkoside demonstrated antiinflammatory activity (AIA) in a variety of test models. Significant AIA was recorded in adjuvant-induced and formaldehyde arthritis in rats and mice. In carrageenan-induced oedema inhibitory activity was remarkably enhanced upon intraperitoneal treatment in rats and mice. Kutkin exhibited significant action in dextran-induced oedema in rats. It inhibited acetic acid induced vascular permeability in mice and leucocyte migration in rats. Kutkin lacked any analgesic, antipyretic or ulcerogenic effect. |
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| Keywords: | Picrorhiza kurrooa kutkin antiinflammatory activity adjuvant arthritis |
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