Human parvovirus B19-induced aplastic crisis in iron deficiency anemia |
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| Authors: | TOORU KUDOH YUKO YOTO NOBUHIRO SUZUKI TAKANORI ODA SHIZUE KATOH SHUNZO CHIBA YASUKO MATSUNAGA |
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| Affiliation: | 1. Department of Pediatrics, School of Medicine, Sapporo Medical University, Sapporo, Tokyo, Japan;2. Central Virus Diagnostic Laboratory, The National Institute of Health, Tokyo, Japan |
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| Abstract: | Human parvovirus B19 (HPVB19) infects and replicates in erythroid progenitor cells. Its specific cytotoxic effect on these cells results in aplastic crises in patients with congenital hemolytic anemias. Aplastic crisis due to HPVB19 infection in a healthy girl revealed occult iron deficiency anemia. The condition is characterized by a high serum iron level in the aplastic phase and rapid recovery after administration of iron. Temporary HPVB19-induced red blood cell aplasia could occur in patients with other anemias, particularly those with non-inherited form of hemolysis. |
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| Keywords: | aplastic crisis human parvovirus B19 iron deficiency anemia |
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