1H editing of 2-deuterated exogenous and natural endogenous D-glucose in biological samples |
| |
| Authors: | Monique Biesemans François Kayser Marc Van Cauteren Nancy J Rehrer Peter Neirinck Kenny De Meirleir Willy J Malaise Rudolph Willem PhD |
| |
| Institution: | 1. VUB, High Resolution NMR Centre, Free University of Brussels, Belgium;2. VUB, Biomedical MR Centre of the Academic Hospital, Free University of Brussels, Belgium;3. VUB, Human Physiology and Sports Medicine Department, Free University of Brussels, Belgium;4. ULB, Laboratory of Experimental Medicine, Erasmus Medical School, Free University of Brussels, Belgium |
| |
| Abstract: | A spin-echo based 1H homonuclear pulse sequence, enabling the selective editing of homonuclear first-order J-multiplet types, is presented and analyzed. Its effectiveness in quantification applications is assessed. Its potential usefulness in the quantitative distinction between 2-deuterated and natural D -,glucose in biological samples is briefly discussed, with emphasis on studies of hexose metabolism conducted in vitro. |
| |
| Keywords: | 1H NMR editing J-modulation glucose quantification plasma glucose |
|
|
