| 拉米夫定治疗慢性乙型肝炎的病原学研究 |
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| 引用本文： | 李宜,高人焘,周陶友,刘小波.拉米夫定治疗慢性乙型肝炎的病原学研究[J].安徽医科大学学报,2002,37(3):206-208. |
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| 作者姓名： | 李宜 高人焘 周陶友 刘小波 |
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| 作者单位： | 1. 安徽省立医院传染科,合肥,230001;2. 四川大学生命科学院,成都,610041 |
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| 摘 要： | 目的观察拉米夫定治疗对慢性乙肝患者体内HBVDNA的影响.方法对拉米夫定治疗组31例(po,100mg/d,25周)和对照20例组进行HBV DNA的斑点杂交和PCR半定量检测;未阴转者扩增含YMDD编码区的基因片段测序.结果拉米夫定治疗组4周、8周、24周、52周HBVDNA阴转率分别为55%、68%、80%、73%,远高于对照组(P＜0.05);治疗组的YMDD变异株检出率亦高于对照组.结论拉米夫定对HBV有较强的抑制作用,但同时诱发较多的YMDD变异.
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| 关 键 词： | 肝炎 乙型 慢性 拉米夫定/治疗应用 |
| 文章编号： | 1000-1492(2002)03-0206-03 |
| 修稿时间： | 2002年2月25日 |
Pathogenic study of chronic hapatitis B treated by lamivudine |
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| Li Yi,Gao Rentao,Zhou Taoyou,et al.Pathogenic study of chronic hapatitis B treated by lamivudine[J].Acta Universitis Medicinalis Anhui,2002,37(3):206-208. |
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| Authors: | Li Yi Gao Rentao Zhou Taoyou |
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| Abstract: | Objective To evaluate the effect of lamivudine on chronic hepatitis B. Methods HBV DNA weredetected in test and control group using dot blot and semiquantitative PCR; Part of HBV DNA including YMDD code region were amplified and sequenced for the patients positive at the end. Results HBV DNA negative rate was 55%, 68%,80%,73%, respectively and 5 YMDD mutant viruses were detected in test group. There is significant difference between test group and control group. Conclusions HBV was inhibited by lamivudine, and more YMDD mutants were induced |
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| Keywords: | hepatitis B chronic/drug therapy Lamivudine/therapeutic use |
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