Lymphocyte subsets in patients with compositae oleoresin dermatitis and increased UVA sensitivity during treatment with azathioprine |
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Authors: | O Baadsgaard C Geisler T Plesner K Thestrup-Pedersen |
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Institution: | (1) Department of Dermatology, Gentofte Hospital, Niels Andersensvej 65, DK-2900 Hellerup, Denmark;(2) Department of Clinical Chemistry, The Finsen Institute, Copenhagen, Denmark;(3) Department of Dermatology, Marselisborg Hospital, Aarhus, Denmark |
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Abstract: | Summary Four patients with severe contact dermatitis resulting from compositae oleoresin were found to have increased sensitivity to ultraviolet light. All showed a clear reduction of Leu-3a-positive lymphocytes (T helper/inducer cells) and cells expressing the Ia phenotype in their blood. The numbers of T suppressor/cytotoxic (Leu 2a) lymphocytes, monocytes and B lymphocytes were within the normal range. Treatment with azathioprine (150 mg daily) improved the eczema. The number of Leu-3a-positive lymphocytes normalized during therapy, but the number of Ia-positive cells did not. |
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Keywords: | Azathioprine Compositae oleoresins Contact dermatitis Ia-Positive cells T Helper/inducer cells (Leu 3a) |
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