隔物灸治疗原发性痛经寒湿凝滞型的临床观察

目的 观察隔物灸治疗原发性痛经寒湿凝滞型的疗效,探讨其作用机制.方法 将209例原发性痛经寒湿凝滞型患者随机分为2组,治疗组105例,采用隔物灸神阙、关元穴治疗,并设口服月月舒冲剂104例为对照组.治疗后进行疗效评价,同时随机对部分患者治疗前后及正常人经期血清前列腺素F_(2α)(PGF_(2α))、血浆血管加压素(AVP)含量进行检测.结果 治疗组疗效明显优于对照组(P＜0.01).2组治疗前血清PGF_(2α)、血浆AVP含量均较正常组明显升高(P＜0.01);2组治疗后血清PGF_(2α)、血浆AVP含量均较治疗前明显降低(P＜0.01,P＜0.05).治疗后2组间血清PGF_(2α)含量比较,差异有统计学意义(P＜0.05);对照组血清PGF_(2α)含量仍较正常组高(P＜0.05).结论 隔物灸对原发性痛经寒湿凝滞型患者有明显的治疗作用,其作用机制可能与降低血清PGF_(2α)及血浆AVP水平有关.

Indirect moxibustion in treatment of primary dysmenorrhea of cold-damp coagulation type

Objective To observe the curative effect of indirect moxibustion in the treatment of primary dysmenorrhea of cold-damp coagulation type and study the mechanism.Methods All 209 patients withprimary dysmenorrhea of cold-damp coagulation type were randomly divided into the treatment group(n=105)treated with indirect moxibustion on the acupoints of Shenque(CV8)and Guanyuan(CV4),and the control group(n=104)treated with Yueyueshu Granules orally.After the treatment the curative effects were reviewed.The levels of menstrual serum prostaglandin F_(2α)(PGF_(2α))and plasma arginine vasopressin(AVP)were detected before and after the treatment in parts ofpatients randomly and normal women.Results The curative effect of the treatment group was much better than that of the control group (P＜0.01).Before the treatment the levels of serum PGF_(2α) and plasma AVP in two groups increased significantly than those in the normal women(au P＜0.01),while after the treatment those decreased significantly(P＜0.01,P＜0.05).The comparison of PG_(2α)level between two groups showed a statistical difference(P＜0.05),but the level of serum PGF_(2α) was higher in the control group than that in normal women(P＜0.05).Conclusion Indirect moxibustion had significant therapeutic effect on primary dysmenorrhea of cold-damp coagulation type,and the mechanism may be related to that it can reduce the levels of seFIlm PGF_(2α) and plasma AVP.