| 环孢素A治疗再生障碍性贫血体外药敏试验的初步研究 |
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| 引用本文： | 李慧慧,杨碧云,涂梅峰,饶燕飞,吴东升. 环孢素A治疗再生障碍性贫血体外药敏试验的初步研究[J]. 江西医学院学报, 2002, 42(2): 79-80 |
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| 作者姓名： | 李慧慧 杨碧云 涂梅峰 饶燕飞 吴东升 |
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| 作者单位： | 江西医学院第二附属医院血液科，江西南昌330006 |
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| 摘 要： | 目的：为预测环孢素A（CSA）治疗再生障碍性贫血（AA）疗效而建立体外药敏试验。方法：采用微量甲基纤维素半固体培养粒一单核细胞集落（GM－CFU），并用CSA干预。结果：体外／体外（S：敏感，R耐药）：S／S11例，R／R10例，R／S：20例，与临床总符合率51．2％，阳性符合率100％，阴性符合率33．3％，试验敏感性35．35％，特异性100％，结论：CSA体外敏感试验与临床疗效有一定相关性，如体外敏感，则体内100％敏感，但存在一定假阴性。
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| 关 键 词： | 再生障碍性贫血 环孢霉素A 药物敏感性试验 体外研究 |
| 文章编号： | 1000-2294(2002)02-0079-02 |
| 修稿时间： | 2001-11-21 |
Study of Sensitivity Test of Cyclosporin A in Aplastic Anemia |
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| LI Hui hui,YANG Bi yun,TU Mei feng,RAO Yan fei,WU Dong sheng. Study of Sensitivity Test of Cyclosporin A in Aplastic Anemia[J]. Acta Academiae Medicinae Jiangxi, 2002, 42(2): 79-80 |
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| Authors: | LI Hui hui YANG Bi yun TU Mei feng RAO Yan fei WU Dong sheng |
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| Abstract: | Objective:To find a method of testing cyclosporin A(CSA) sensitivity for aplastic anemia (AA) in vitro. Methods: Methylcellulose semi solid cultures were used to assess GM-CFU colonies to estimate the sensitivity of AA to CSA. Results: There were 11 S (sensitive)/S (in vitro/in vivo), 10 R(resistant)/R, 20R/S in 41 Patients. In general, Positive and negative coincident rates of in vitro with thoses of in vivo, specificity, and sensitivity were 51.2%,100%,35.35%,100%,33.3%, resectively. Conlusion: The method gives a good predicitive value for the therapy of AA. If it is sensitive in vitro, rate of sensitivity in vivo is 100%, but there are some false negative. |
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| Keywords: | anemia aplastic cyclosporin A drug sensitivity test in vitro |
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