| APOLIPOPROTEIN E POLYMORPHISM AND ALZHERMER‘ S DISEASE |
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| 引用本文： | 张曙云,葛炜,程吟梅,朱建中.APOLIPOPROTEIN E POLYMORPHISM AND ALZHERMER‘ S DISEASE[J].中国医学科学杂志,1998,13(2):123-125. |
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| 作者姓名： | 张曙云 葛炜 程吟梅 朱建中 |
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| 作者单位： | Hangzhou Sanatorium of PLA，Hangzhou 310007 |
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| 摘 要： | INTRODUCTIONAlzhelmer'sdisease(AD),whichseriouslyaffectedthehealthyoftheagedpeople,canbehardlycured.ApoEIsuniqueamongapollpoproteininthatithasaspecialrelevancetonervoustissue(l).ButtherewerefewreportsontherelationshipbetweenApoEpolymorphismandADinourcountry.Therefore,wedeterminedandanalysedtheApoEpolymorphismof30sporadicAD,27patientswithMIDand46agedhealthysubjectsascontrol.ThepurposeistoinquireintotherelationshipoftheApoEgenepolymorphismandthesporadicADinChinese.MFTERIALSANDM…
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| 关 键 词： | 阿朴脂蛋白E 基因多态性 阿海默茨病 发病机制 老年人 |
APOLIPOPROTEIN E POLYMORPHISM AND ALZHERMER'S DISEASE |
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| Zhang Shuyun,Ge Wei,Cheng Yinmei and Zhu Jianzhong.APOLIPOPROTEIN E POLYMORPHISM AND ALZHERMER'S DISEASE[J].Chinese Medical Sciences Journal,1998,13(2):123-125. |
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| Authors: | Zhang Shuyun Ge Wei Cheng Yinmei and Zhu Jianzhong |
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| Abstract: | We determined and analysed the ApoE polymorphism of 30 sporadic Alzheimer's disease (AD) pa- tients, 27 patients with multi-infarct dementia (MID) and 46 aged healthy subjects as control. The results showed that the frequency of ApoE E4/3 genetype in AD group was significantly higher than that in con- trol (P<0. 05). Among these three groups, ApoE 4 allele frequency in AD group was significantly higher than that in control (P<0. 01 ) and MID group (P<0. 05). Among the three ApoE alleles, the risk ratio of ApoE E4 allele in AD group was 4. 114(p<0. 01 ). There was statistically significant (P<0. 05) as the increasing of ApoE 4 gene dose in AD. It suggests that ApoE is related to AD of Chineses and it might be a genetics index of early diagnosis for AD. |
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| Keywords: | apolipoprotein E polymorphism Alzheimer's disease |
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