BCG-induced trained immunity in NK cells: Role for non-specific protection to infection |
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| Authors: | Johanneke Kleinnijenhuis Jessica Quintin Frank Preijers Leo AB Joosten Cor Jacobs Ramnik J Xavier Jos WM van der Meer Reinout van Crevel Mihai G Netea |
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| Institution: | 1. Department of Internal Medicine, Radboud University Medical Centre, 6525 GA Nijmegen, The Netherlands;2. Department of Laboratory Medicine — Laboratory of Hematology, Radboud University Medical Centre, 6525 GA Nijmegen, The Netherlands;3. Center for Computational and Integrative Biology and Gastrointestinal Unit, Massachusetts General Hospital, Harvard School of Medicine, Boston, MA 02114, USA;4. Broad Institute of MIT and Harvard University, Cambridge, MA 02142, USA |
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| Abstract: | Adaptive features of innate immunity, also termed ‘trained immunity’, have recently been shown to characterize monocytes of BCG vaccinated healthy volunteers. Trained immunity leads to increased cytokine production in response to non-related pathogens via epigenetic reprogramming of monocytes. Recently, memory-like properties were also observed in NK cells during viral infections, but it is unknown if memory properties of NK cells contribute to trained immunity due to BCG vaccination. |
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| Keywords: | Trained immunity BCG Innate immunity Vaccination |
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