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Therapy of type 1 diabetes with CD4CD25CD127-regulatory T cells prolongs survival of pancreatic islets — Results of one year follow-up
Authors:Natalia Marek-Trzonkowska  Małgorzata Myśliwiec  Anita Dobyszuk  Marcelina Grabowska  Ilona Derkowska  Jolanta Juścińska  Radosław Owczuk  Agnieszka Szadkowska  Piotr Witkowski  Wojciech Młynarski  Przemysława Jarosz-Chobot  Artur Bossowski  Janusz Siebert  Piotr Trzonkowski
Institution:1. Department of Family Medicine, Medical University of Gdańsk, D?binki 2, 80-210 Gdańsk, Poland;2. Department of Pediatric Diabetology and Endocrinology, Medical University of Gdańsk, D?binki 7, 80-210 Gdańsk, Poland;3. Department of Clinical Immunology and Transplantology, Medical University of Gdańsk, D?binki 7, 80-210 Gdańsk, Poland;4. Regional Center of Blood Donation and Treatment, Hoene-Wrońskiego, 180-210, Gdańsk, Poland;5. Department of Anesthesiology and Critical Care, Medical University of Gdańsk, D?binki 7, 80-210 Gdańsk, Poland;6. Department of Pediatrics, Oncology, Hematology and Diabetology, Medical University of ?ód?, Sporna 36/50, 91-738 ?ód?, Poland;g Department of Surgery, Section of Transplantation, The University of Chicago, 5841 S. Maryland Ave. MC5027, Chicago, 60637 IL, USA;h Department of Pediatrics, Endocrinology and Diabetes, Medical University of Silesia, Poniatowskiego 15, 40-055 Katowice, Poland;i Department of Pediatrics Endocrinology and Diabetology, Medical University of Bia?ystok, Jana Kilińskiego 1, 15-089 Bia?ystok, Poland
Abstract:It is hypothesized that CD4+CD25+FoxP3+ regulatory T cells (Tregs) can prevent destruction of pancreatic islets protecting from type 1 diabetes (DM1).
Keywords:anti-GAD  glutamic acid decarboxylase autoantibodies  anti-IA2  tyrosine phosphatase-related islet antigen 2 autoantibodies  b  w  body weight  cGMP  current good manufacturing practice  DDI  daily dose of insulin  DM1  type 1 diabetes mellitus  GvHD  graft versus host disease  HEPA  high-efficiency particulate absorption  IAA  insulin autoantibodies  ICA  islet cell autoantibodies  IFNγ  interferon γ  Tregs  T regulatory cells  HBV  hepatitis B virus
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