| 多西他赛与下肢水肿相关 |
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| 引用本文： | 沈泽天,王立峰,钱晓萍,刘宝瑞. 多西他赛与下肢水肿相关[J]. 药物不良反应杂志, 2008, 10(1): 60-61 |
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| 作者姓名： | 沈泽天 王立峰 钱晓萍 刘宝瑞 |
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| 作者单位： | 南京大学医学院附属鼓楼医院肿瘤中心,南京210008 |
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| 摘 要： | 1名61岁男性胃癌晚期患者，术后化疗给予多西他赛40mg／m^2静脉滴注，亚叶酸钙120mg／m^2静脉滴注，氟尿嘧啶800mg／m^2 24h中心静脉持续滴注，配合羟基喜树碱15mg腹灌和热疗2个周期。用药结束后第5天患者出现双下肢进行性可凹性水肿。给予甲泼尼龙、呋塞米治疗4d后，水肿消退。
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| 关 键 词： | 多西他赛 下肢水肿 |
Oedema of lower extremities associated with docetaxel |
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| Shen Zetian,Wang Lifeng,Qian Xiaoping,Liu Baorui. Oedema of lower extremities associated with docetaxel[J]. Adverse Drug Reactions Journal, 2008, 10(1): 60-61 |
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| Authors: | Shen Zetian Wang Lifeng Qian Xiaoping Liu Baorui |
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| Affiliation: | ( Department of Oncology, Gulou Hospital Affiliated to Medical College of Nanfing University, Nanjing 210008, China ) |
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| Abstract: | A 61 year-old man with advanced gastric carcinoma received chemotherapy with IV docetaxel 40 mg/m^2 , IV calcium folinate 120 mg/m^2, and fluorouracil 800 mg/m^2 via a central vein for 24 hours, in combination with two cycles of intraperitoneal hydroxycamptothecin 15 mg and thermotherapy after the surgery. On day 5 after the chemotherapy, he developed progressive pitting oedema of the lower extremities. After 4 days of treatment with methylprednisolone and furosemide, his oedema resolved. |
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| Keywords: | docetaxel oedema of lower extrmities |
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