脑梗死患者外周血与颈动脉斑块内脂蛋白相关磷脂酶A2表达的相关性 |
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引用本文: | 何毅,伍健明,张猛,刘晓佳,张协军,张秋生,黄贤键.脑梗死患者外周血与颈动脉斑块内脂蛋白相关磷脂酶A2表达的相关性[J].中国实用神经疾病杂志,2016(23):9-11. |
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作者姓名: | 何毅 伍健明 张猛 刘晓佳 张协军 张秋生 黄贤键 |
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作者单位: | 广东深圳市第二人民医院神经外科 深圳 518035 |
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基金项目: | 深圳市科技计划项目(JCYJ20140414170821291) |
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摘 要: | 目的探讨外周血与颈动脉斑块内脂蛋白相关磷脂酶A2(Lp-PLA2)表达的相关性。方法选择颈内动脉系动脉粥样硬化性脑梗死患者37例为研究对象,采用彩色多普勒超声对斑块类型进行划定,采用免疫增强比浊法测定血浆和斑块组织提取物中Lp-PLA2含量后行相关性分析。结果 F检验显示,斑块类型对血浆Lp-PLA2水平有影响(P0.05)。进一步采用SNK-q检验显示,Lp-PLA2水平变化关系:无斑块组稳定粥样斑块组不稳定粥样斑块组,两两比较差异均有统计学意义(P0.05)。脑梗死患者外周血与颈动脉斑块内Lp-PLA2表达相关性对比发现,2个部位该蛋白的表达呈正相关(r=0.831,P=0.008)。结论 Lp-PLA2可能是颈动脉不稳定粥样斑块的临床标志物,外周血与颈动脉斑块内Lp-PLA2表达呈线性正相关。
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关 键 词: | 脑梗死 Lp-PLA2 颈动脉不稳定粥样斑块 |
The relationship between Lp-PLA2 expression in peripheral blood and carotid plaques of cerebral infarc-tion patients |
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Abstract: | Objective To explore the association between Lp-PLA2 expression in peripheral blood and carotid plaques of cerebral infarction patients.Methods A total of 37 carotid artery atherosclerosis of the acute cerebral infarction(ACI)patients were enrolled as the research objects.The color Doppler ultrasound was used to discriminate the type of these plaques.In addi-tion,immune enhancement turbidimetry was applied to examine the expression of Lp-PLA2 in peripheral blood and carotid plaques.Results F-test showed that the Lp-PLA2 expression was influenced by the type of plaque(P <0.05 ).In addition, SNK-q test revealed the concentration changes of Lp-PLA2:cerebral infarction without plaque group < stable atheromatous plaque group
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Keywords: | Cerebral infarction Lp-PLA2 Unstable carotid atheromatous plaque |
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