| 儿童艰难梭菌感染 |
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| 引用本文： | 郑跃杰,张国成.儿童艰难梭菌感染[J].临床儿科杂志,2011,29(6). |
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| 作者姓名： | 郑跃杰 张国成 |
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| 作者单位： | 1. 深圳市儿童医院,广东深圳,518026
2. 第四军医大学西京医院儿科,陕西西安,710032 |
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| 摘 要： | 随着广谱抗生素的大量使用,艰难梭菌相关性腹泻(CDAD)的发生率明显上升,特别是高毒力株(027/NAP1/BI)在欧美的出现及流行,已经引起全世界的关注.CDAD的临床症状轻重不一,可从轻度腹泻到致死性假膜性肠炎和中毒性巨结肠.CDAD的确诊依赖于实验室检查,包括厌氧菌培养及细胞毒性试验、细菌毒素抗原检测、毒素基因扩增检测.处理包括停用相关抗生素,尽早应用甲硝唑或万古霉素,以及益生菌药物.
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| 关 键 词： | 艰难梭菌 肠炎 诊断 治疗 |
Clostridium difficile infection in children |
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| ZHENG Yue-jie,ZHANG Guo-cheng.Clostridium difficile infection in children[J].The Journal of Clinical Pediatrics,2011,29(6). |
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| Authors: | ZHENG Yue-jie ZHANG Guo-cheng |
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| Institution: | ZHENG Yue-jie1,ZHANG Guo-cheng2(1.Shenzhen Children's Hospital,Shenzhen 528026,Guangdong,China,2.Department of Pediatrics,Xijing Hospital,The Fouth Military Medical University,Xi'an 710032,Shaanxi,China) |
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| Abstract: | With extensive use of broad-spectrum antibiotics,the incidence of clostridium difficile associated diarrhea(CDAD)has increased dramatically.The emergence and outbreak of hypervirulent C.difficile strain(027/NAP1/BI)in Europe and North American have become a worldwide public concern.CDAD has a wide range of clinical features from mild diarrhea to life-threatening pseudomembrannous colitis and toxic megacolon.The diagnosis of CDAD is dependent on the laboratory assays including anaerobic bacteria culture and ... |
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| Keywords: | Clostridium difficile colitis diagnosis therapy |
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